Dietary supplements Supplementation

Sunifiram and piracetam – what are those substances?

What is sunifiram?

The above compound belongs to the group of synthetic derivatives of Piracetam. DM-235 is also a nootropic medicine that strengthens cognitive processes. Very often it’s referred to as AMPAkine due to its action through the AMPA receptor and kainic acid.

Sunifiram – properties

The action of sunifiram is very similar to its precursor – this nootropic drug is responsible for improving the metabolism of the nervous system, which promotes the efficiency and effectiveness of energy transformation. Due to the low level of toxicity and the greater (almost 1000 times) nervous system impact power than Piracetam, it’s increasingly used in the treatment of neurological problems. Sunifiram is also responsible for oxygenating the brain, improving the blood circulation, and also affecting the production of acetylcholine.


Sunifiram is recommended for:

– improving intellectual performance;

– improvement of cognitive functions;

– increase in the productivity of professionally active people;

– metabolism stimulation.


Due to the lack of detailed human studies, it’s very difficult to determine the optimal dose of sunifiram. Estimated doses were calculated on the basis of tests on rats, in which the optimal supplementation is about 1 mg per kilogram of body weight. Therefore, it’s assumed that a human should use from 0.08 to 0.16 mg of substance for every kilogram creating the mass of their own body.

Piracetam – reviews, dosage

Nootropics are substances that improve both the brain and the nervous system. These preparations are increasingly finding supporters not only among the sick, but healthy people who are subjected to excessive intellectual effort. Are “smart drugs” really safe and beneficial to our body? More


  1. What is piracetam?

Piracetam is a nootropic drug belonging to the group of compounds called pyrrolidones. This compound is a derivative of the very well-known γ-amino-butyric acid (GABA). Nootropic drugs are substances of various structure and mechanism of action, but they are compatible with the metabolism of the central nervous system. The effect of this can be the stimulation of memory processes and awareness. Piracetam is a substance that does not show physical dependence.

Piracetam – action

Piracetam is a substance used in the treatment of pathological conditions of neurological background. Responsible primarily for enhancing the metabolism of neurons in states of reduced activity. This leads to improved nerve conduction, increased use of oxygen and glucose, improved synthesis of neurotransmitters and high energy compounds. Piracetam also has strong antimonlonic activity.


The above reactions have a very positive effect on the activity of the higher parts of the central nervous system. What’s more, they lead to the improvement of cognitive processes (e.g. memory, consciousness or learning) and psychophysical efficiency. It’s worth adding that Piracetam in people with dyslexia improves the speed of reading and improves the process of memorizing. In addition, this compound is used as part of the prevention of brain function changes.


Another important action of Piracetam is its impact on the cardiovascular system. Among the numerous impacts, it’s worth specifying:

– lowering of blood and plasma viscosity;

– stimulation of prostacyclin synthesis;

– removal of pathological spasms of small vessels;

– reduction of the aggregating ability of thrombocytes (platelets);

– limitation of adherence of erythrocytes to the endothelium of blood vessels;

– prolonged bleeding time and decreased fibrinogen levels.


The standard dose of Piracetam for children is between 40 and 100 mg of substance for every kilogram of body weight. In the treatment of dyslexia, lower doses, not exceeding 50 mg, are also used. In turn, adults should use between 1200 and 4800 mg per day. The maximum effectiveness is shown by the maximum dose divided into three servings during the day of 1600 mg each.



A study conducted on healthy young volunteers aimed to demonstrate the effectiveness of Piracetam supplementation in the context of improving brain function. Despite the lack of any impact in the normal situation, the results confirmed the assumption. Participants were subjected to a situation of inadequate oxygenation of the brain (excessive concentration, sleepless night), followed by an EEG test. The analysis showed improvement in the efficiency of brain work after the earlier use of the nootropic drug.

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